Contents: Wnt/beta-catenin signaling
Wnts: secreted proteins that signal at close range
PORCN therapeutic opportunity
The Porcn-WLS-Wnt secretion cycle
Regulation at the membrane
Diverse approaches to inhibiting Wnt signaling
beta-catenin target genes
An approach to treating Wnt-addicted cancers
PORCN inhibitor ETC-159.